氨苯砜对高危人群预防麻风效果的前瞻性观察

Prospective observation on the effect of dapsone in prevention of leprosy in high risk populations

目的研究高危儿童应用氨苯砜预防麻风病的效果。方法选择住院麻风病人在院内生育的76名子女为预防组,应用氨苯砜(DDS)作预防用药,用药时间2年;治愈出院病人在院外生育的87名子女为对照组,用维生素B1作安慰剂,并对两组进行比较。结果随访观察的163人中,完成25年全程随访者152人,占93.25%。预防组未见发病者,而对照组先后有8人发病,发病率为9.2%。结论DDS预防麻风显示有效,且具有近、中期的预防效果。

Objective To analyze the effect of dapsone on leprosy in high risk population. Methods Seventy - six offsprings born by hospitalized leprocy parents in leprosarium were selected as observation group and dapsone was geiven as prophylactic in a course of two years; eighty - seven offsprings born by discharged leprocy patients after recovery in leprosarium were selected as control group and vitamin Blwas used as placebo and then the two groups were compared. Results 152 of them were followed up for 25 years accounted for 93.25 %. No leprosy patient was found in observation group, whereas 8 cases were detected in the control group with a morbidity rate of 9.2 %. Conclusion Dapsene is effective for preventing leprosy.