心肌缺血预适应对老年心肌梗死范围和预后的影响

Effects of ischemic preconditioning on size and short-term prognosis of myocardial infarction in the aged

目的研究缺血预适应对老年心肌梗死范围和预后的影响。方法将120例首次老年心肌梗死患者依据梗死前有无心绞痛发作分为缺血预适应组(74例)和非缺血预适应组(46例),通过心电图计分法和磷酸肌酸激酶峰值水平比较最初心肌梗死面积;并统计两组出现并发症和住院期间病死率。结果心肌梗死中确存在缺血预适应,缺血预适应组在最初心肌梗死面积和严重并发症(心源性休克、急性肺水肿和恶性心律失常等)均少于非缺血预适应组(P<0.05)。结论心肌梗死前的心肌缺血预适应对老年心肌梗死患者的心肌有一定的保护作用。

Objective To investigate the effects of myocardial ischemic preconditioning on size and prognosis of myocardial infarction in the aged.Methods 120 aged patients with first-time myocardial infarction（MI） were divided into the preconditioning group and the non-preconditioning group according to whether angina pectoris attacks had occurred before infarction. The initial size of MI was compared by ECG scoring and peak value of CK. The rate of complication and mortality during period of hospitalization were calculated. Results Ischemic preconditioning indeed existed in MI. Compared with non-preconditioning group, the initial size of infarction of the preconditioning group was smaller and some complications, such as cardiogenic shock, acute pulmonary edema and malignant arrhythmia, were less frequent （ P 〈 0.05）. Conclusion Ischemic preconditioning before MI has protective effect on myocardium of the aged against myocardial infarction.