正电子发射型计算机断层仪、前哨淋巴结技术及放射免疫治疗头颈肿瘤的新进展

The value of positron emission tomography(PET) and sentinel node(SN) technique and radioimmunotherapy(RIT) in the treatment of head and neck cancer

由于早期诊断肿瘤手段的局限性,限制了临床对某些头颈鳞状细胞癌病人行正确的选择性颈部治疗。肿瘤伴有淋巴结转移则是最不利的预后因素。伴有颈部淋巴结转移的病人,5年存活率降低50%。因为肿瘤浸润的范围和(或)肿瘤的大小不能作为判断是否有颈淋巴结转移的指标,故有时侯即使很小的原发肿瘤也常常伴有颈部转移。本文就正电子发射型计算机断层仪、前哨淋巴结技术以及以辅助治疗为目的的放射免疫治疗的发展现状及前景进行论述。

There is a constant search for diagnostic modalities which are now limiting elective neck treatment to selected patients with squamous cell carcinoma in the head and neck region. The presence of lymph node metastases is the single most adverse independent prognostic factor. The 5-year overall survival rate reduces by about 50 % in patients with cervical lymph node metastases. Cervical lymph node metastases can not always be predicted from the size and/or extent of invasion of the primary cancer. Even cases with small primary tumours have frequently cervical lymph node metastases. Current situation on positron emmision tomography, sentinel node, and radioimmunotherapy has been demonstrated in this paper.