新型C_2对称的手性双席夫碱的设计合成及结构表征

Synthesis and characterization of novel C_2 symmetric chiral bidentate Schiff′s base

以天然产物奎宁为原料,经亲核取代,还原得到9-氨基奎宁,进而和邻苯二甲醛生成C2对称的手性双席夫碱,总产率达到53%,重要中间体和目标产物的结构经MSI、R1、HNMR和元素分析得到确证。

A novel C2 symmetric chiral bidentate Schiff＇ s base was synthesized conveniently from phthalaldehyde and 9-amino （9-deoxy） quinine, which was prepared from natural quinine via nucleophilic substitution and catalytic reduction. The total chemical yield of chiral bidentate Schiff＇ s base was 53 %. The structures of the main intermediates and the aim product were established by MS, IR, ^1HNMR and elemental analysis.