摘要
以天然产物奎宁为原料,经亲核取代,还原得到9-氨基奎宁,进而和邻苯二甲醛生成C2对称的手性双席夫碱,总产率达到53%,重要中间体和目标产物的结构经MSI、R1、HNMR和元素分析得到确证。
A novel C2 symmetric chiral bidentate Schiff' s base was synthesized conveniently from phthalaldehyde and 9-amino (9-deoxy) quinine, which was prepared from natural quinine via nucleophilic substitution and catalytic reduction. The total chemical yield of chiral bidentate Schiff' s base was 53 %. The structures of the main intermediates and the aim product were established by MS, IR, ^1HNMR and elemental analysis.
出处
《化学试剂》
CAS
CSCD
北大核心
2006年第6期321-322,348,共3页
Chemical Reagents
基金
国家自然科学基金资助项目(20372083)
陕西省自然科学基金资助项目(2002B20)
关键词
C2对称
手性双席夫碱
合成
C2 symmetric
chiral bidentate Schiff' s base
synthesis