软坚消瘿汤治疗慢性淋巴细胞性甲状腺炎的临床研究

Effects of Ruanjian Xiaoying Decoction on chronic lymphocytic thyroiditis

目的观察软坚消瘿汤治疗慢性淋巴细胞性甲状腺炎的临床疗效。方法80例慢性淋巴细胞性甲状腺炎患者随机分为软坚消瘿汤治疗组和西药治疗组,每组40例。治疗16周后,检测两组患者甲状腺功能及血清抗甲状腺自身抗体滴度水平,并进行临床疗效评价。结果软坚消瘿汤治疗组总有效率92.5%,西药治疗组总有效率60.0%,两组比较差异有统计学意义。两组患者经治疗后,血清游离三碘甲状腺原氨酸、游离甲状腺素水平均较治疗前明显升高,差异有统计学意义;而血清促甲状腺素水平、血清抗甲状腺球蛋白抗体及抗甲状腺微粒体抗体滴度水平则均较治疗前明显下降,差异有统计学意义。结论软坚消瘿汤具有较好的软化、缩小肿大甲状腺及其结节的作用,可以提高机体的免疫功能、减轻甲状腺的自身免疫反应、促进甲状腺细胞功能的恢复。

Objective： To evaluate the clinical outcome of Ruanjian Xiaoying Decoction （RJXYD） on chronic lymphocytic thyroiditis. Methods. Eighty patients with chronic lymphocytic thyroiditis were randomly divided into RJXYD-treated group （n = 40） and control group （n = 40）. The patients in the RJXYD-treated group received treatment of RJXYD combined with levothyroxine while the others in the control group received treatment of levothyroxine and prednisone both for 16 weeks. The serum levels of thyroid hormones and the titres of serum antithyroglobulin antibody （anti-TG Ab） and antithyroid microsomal antibody （anti-TM Ab） were all examined before and after treatment. The total response rates of the two groups were evaluated after treatment of 16 weeks. Results： The total response rate of the RJXYD-treated group was 92.5%, while that of the control group was 60.0% （ P〈0. 01）. The serum levels of free triiodothyronine （FT3） and free thyroxine （FT4） were obviously increased after treatment as compared with those before treatment in the two groups. The titres of serum anti-TG Ab and anti-TM Ab and the serum level of thyroid-stimulating hormone （TSH） were all obviously decreased after treatment as compared with those before treatment in the two groups. Conclusion： The RJXYD can shrink and soften the enlarged thyroid gland and thyroid nodules, improve the immune function of human body, alleviate the response to thyroid self-antigens and promote the recovery of thyroid function.