毛细胞白血病中毛细胞的超微结构特征

Ultrastructure characteristics of hairy cell in hairy cell leukemia

应用透射电镜观察6例毛细胞白血病(HCL)患者外周血、骨髓血和脾细胞悬液中毛细胞的超微结构特征。结果显示,毛细胞表面微绒毛较多,呈细长指状或环状,或为粗大细胞突起;胞质内细胞器丰富,偶见核糖体-板层复合体(RLC)。结果提示毛细胞表面的微绒毛是HCL超微病理诊断的重要依据,而RLC是HCL诊断和治疗的参考依据。

The ultrastructure characteristics of hairy cell in peripheral blood,bone marrow blood and suspension of spleen cell from six patients with hairy cell leukemia（HCL） were observed under electron microscope. The result showed that there were many micravilli on the surface of hairy cell. The micravilli showed different shapes, of thin finger or ring. The ribosome lamellar complex（RLC） in the cytoplasm of hairy cell can be found occasionally. These results demonstrate that micravilli on the surface of hairy cell is an important morphology diagnosis evidence of HCL and the RLC in the cytoplasm is the reference evidence to diagnosis and therapy of HCL.