补肾强督方治疗强直性脊柱炎患者259例临床研究

Clinical Study on Bushen Qiangdu Recipe for Treatment of 259 Cases of Ankylosing Spondylitis

目的探讨补肾强督方治疗强直性脊柱炎(AS)的临床疗效与安全性。方法本研究共入选259例门诊和住院患者,予补肾强督方治疗,每日1剂,早晚分服,疗程6个月,治疗前后评价如下疗效指标患者健康综合评分(BAS-G)、疾病活动指数(BASDAI)、功能指数(BASFI)、全身痛Likert四级评分、脊柱痛Likert四级评分、晨僵时间、医生总体评价、枕墙距、指地距、颌柄距、胸廓活动度、Schober征、脊柱活动度、“4”字试验、血沉(ESR)、C反应蛋白(CRP),并观察血常规、尿常规、肝肾功能等药物安全性指标。结果259例患者经用补肾强督方治疗6个月后,除枕墙距、颌柄距无明显改变外,其余指标均有显著改善。259例患者均未出现血常规、尿常规改变及肝肾功能损害。结论补肾强督方对AS有较好疗效,且安全可靠。

Objective：To explore clinical therapeutic effect and safety of Bushen Qiangdu Recipe on ankylosing spondylitis （AS）. Methods： 259 out-patients and in-patients enrolled were treated with Bushen Qiangdu Recipe for 6 months,one dose each day for oral administration in morning and night. BAS-G,BASDAI,BASFI,Likert＇ 4-grade score of spinal pain, Likert＇ 4-grade score of whole body pain, duration of morning stiffness, evaluation of doctor, the occiput-wall distance, the finger-floor distance, the mandible-stermum distance,chest expansion, Schober＇ test ,the range of spinal movement,Gaenslen＇s sign, ESR, CRP, blood and urine routine examination,renal and hepatic functions were detected before and after treatment. Results：Significant improvement was observed in all indexes except for the occiput-wall distance and the mandible-stermum distance ,and no adverse effect in blood and urine routine examination and renal and hepatic function was found. Conclusion： Bushen Qiangdu Recipe has therapeutic effect on ankylosing spondylitis.