慢性乙型肝炎HBeAg阴性患者乙肝病毒变异与中医辨证分型的关系

Relationship between Hepatitis B Virus Variation and TCM Syndrome Types in HBeAg-Negative Patients of Chronic Hepatitis B

目的探讨慢性乙型肝炎HBeAg阴性患者乙型肝炎病毒(HBV)变异状况与中医辨证分型的关系。方法将84例慢性乙型病毒性肝炎HBeAg阴性患者按中医辨证分为5种证型,采用迈科锐HBV突变检测基因芯片,进行乙型肝炎病毒C基因启动子(BCP)和前C基因终止变异检测。结果与HBeAg阳性组患者相比,HBeAg阴性患者HBV变异的发生与中医各证型无明显相关性;分为偏实证组和偏虚证组后,BCP区和/或前C区变异率偏实证组为34.5%,偏虚证组为65.5%,偏虚证组明显高于偏实证组。结论BCP区和/或前C区变异与中医辨证分型存在相关性,实证变异率低于虚证。

Objective：To probe the relationship between hepatitis B virus （HBV） variation and TCM syndrome types in HBeAg-negative patient of chronic hepatitis B. Methods：Eighty-four cases of HBeAg-negative patient of chronic hepatitis B were divided into 5 syndrome types according to TCM differentiation. C gene promoter （BCP area） and pre-C gene termination variation in HBV were detected with gene chip for HBV mutation detection. Results：There was no significant correlativity between generation of HBV variation and TCM syndrome types in HBeAg-negative patient of hepatitis B as compared with HBeAg-positive patient ;The variation rate of the BCP area and/or the pre-C area was 34.5 % in prevailing excess syndrome group and 65.5 % in the prevailing deficiency group,the former being higher than the latter. Conclusion ：There is correlativity between variation of BCP area and/or pre-C area and TCM syndrome types,with the variation rate of the excess syndrome being lower than that of the deficiency syndrome.