膀胱癌中PGP、MDM2、p53基因表达的意义

Significance of Expression of PGP MDM2 and p53 Protein in Bladder Cancer

目的探讨膀胱癌组织中Pgp、MDM2、p53基因表达的意义。方法采用免疫组织学方法检测83例膀胱移行细胞癌中Pgp、MDM2、p53基因表达的情况。结果Pgp阳性表达率为71.08%,p53阳性表达率为50.6%,MDM2阳性表达率59.03%,MDM2阳性表达与膀胱癌病理分级及临床分期呈负相关(γ=-0.263,P=0.016及γ=-0.388,P=0.001);p53阳性表达与膀胱癌病理分级呈正相关(γ=0.492,P=0.001);Pgp阳性表达与其病理分级及临床分期无相关性;Pgp、MDM2、p533种蛋白表达间无相关性。AI、p53、MDM2表达与患者5年生存率有关。结论检测Pgp可指导膀胱癌化疗药物的选择;运用膀胱癌临床分期及病理分级并检测其p53、MDM2表达,可判断膀胱移行细胞癌的预后。

Objective To research the expression of Pgp MDM2 and p53 protein and its significance in bladder cancers. Methods The expression of Pgp MDM2 and p53 gcne in specimens of 83 cases of patients ,with bladder transitional cell carcinomas were studied by immunohistochemical mcthod. Results Thc positivc expressionrate of Pgp gene was 71.08%, p53 gene was 50.6 % and MDM2 ,was 59.03%. The levcl of MDM2 was negativc correlated with the tumor pathological grade and clinical stage（r = -0. 263, P = 0. 016 ）及γ = -0. 388, P = 0. 001）;The lcvel of p53 was positive corrclated with the tumor pathological grade （γ = 0. 492, P = 0.001） ; The lcvel of Pgp ,was no corrclatcd with the tumor pathological grade and clinical stage; No correlated was found between Pgp MDM2 and p53 gene. AI and the cxpression of p53 and MDM2 werc related to patients,5-year survival ratc. Conclusion To examine Pgp ,is beneficial to .selection of bladder carcinoma chemothcrapeutic medicines. By exerting the tumor pathological grade and clinical stage and dctecting p53 MDM2 genes expressions , the prognosis of bladder cancer can bc decided.