活血化瘀法对子宫内膜异位症模型大鼠E_2、P、VEGF的影响

Effect on Activating Blood and Removing Stasis Prescription on E_2、P、VEGF of Endometriotic Rats

目的:探讨活血化瘀法治疗子宫内膜异位症的作用机理。方法:采用大鼠自体子宫内膜移植建立实验性子宫内膜异位症模型,分别观察活血化瘀方药和达那唑对模型大鼠外周血清E2、P含量及VEGF在大鼠异位内膜组织中的表达的影响。结果:活血化瘀方药对上述指标均有不同的降调或抑制作用,与模型组比较有显著性差异(P<0.05),活血化瘀法高剂量组与达那唑相比无显著性差异(P>0.05)。结论:活血化瘀法具有调节内分泌及血管内皮细胞生长因子作用,能够有效抑制异位子宫内膜的种植。

Objective： To study the effect and mechanism of activating blood and removing stasis prescription on treatment of endometriosis. Methods： To set up endometriosis model by rat self-endometria transplantation, E2、 P of serum and VEGF of endometriosis tissue were dividedly detected. Result： The three parameters were depressed by aetivating blood and removing stasis prescription. There was significant difference of each target between activating blood and removing stasis prescription group and model group （ P 〈 0. 05）. There was no significant difference of each target between the high dose of activating blood and removing stasis prescription group and Danazol group （ P 〉 0. 05）. Conclusion： activating blood and removing stasis prescription can inhibit the growth of endometrial transplants, which is relates with the VEGF of dometriotic tissue and serum hormone, especially Ea.