摘要
目的:探讨活血化瘀法治疗子宫内膜异位症的作用机理。方法:采用大鼠自体子宫内膜移植建立实验性子宫内膜异位症模型,分别观察活血化瘀方药和达那唑对模型大鼠外周血清E2、P含量及VEGF在大鼠异位内膜组织中的表达的影响。结果:活血化瘀方药对上述指标均有不同的降调或抑制作用,与模型组比较有显著性差异(P<0.05),活血化瘀法高剂量组与达那唑相比无显著性差异(P>0.05)。结论:活血化瘀法具有调节内分泌及血管内皮细胞生长因子作用,能够有效抑制异位子宫内膜的种植。
Objective: To study the effect and mechanism of activating blood and removing stasis prescription on treatment of endometriosis. Methods: To set up endometriosis model by rat self-endometria transplantation, E2、 P of serum and VEGF of endometriosis tissue were dividedly detected. Result: The three parameters were depressed by aetivating blood and removing stasis prescription. There was significant difference of each target between activating blood and removing stasis prescription group and model group ( P 〈 0. 05). There was no significant difference of each target between the high dose of activating blood and removing stasis prescription group and Danazol group ( P 〉 0. 05). Conclusion: activating blood and removing stasis prescription can inhibit the growth of endometrial transplants, which is relates with the VEGF of dometriotic tissue and serum hormone, especially Ea.
出处
《成都中医药大学学报》
2006年第2期28-29,33,共3页
Journal of Chengdu University of Traditional Chinese Medicine
基金
黑龙江省自然科学基金资助(No.39670895)