肺炎克雷佰氏菌药敏的临床观察

Clinical observation of drug resistance of pneumonia kleber strains

目的:对196株肺炎克雷佰氏菌药敏分析,为婴幼儿治疗合理用药提供依据。方法:采用美国Microscanautoscan4细菌自动鉴定药敏分析仪。结果判断按美国国家临床实验室标准化委员会(NCCLS)制定标准进行。结果;①出生1～30天患儿肺炎克雷佰氏菌感染率20.9%,1个月～12个月患儿感染率62.3%,高于国内文献报道。②196株肺炎克雷佰氏菌对20种常用抗生素最敏感的是亚胺硫霉素敏感率98.0%,依次是妥布霉素87.8%、丁胺卡那霉素86.2%、呱拉西林84.7%、庆大霉素82.1%、头孢西丁70.9%、环丙氟哌酸68.4%、复方新诺明67.9%,其它12种抗生素耐药率达56.6%～94.9%。结论:婴幼儿细胞及体液免疫功能差,妇幼保健院应加强围产期及婴幼儿健康保健工作。肺炎克雷佰氏菌耐药的危险性,应引起相关医务工作者高度重视。

Objective： To provide reliable drug - treated evidence for infant treatment via the drug resistance analysis of 196 pneumonia kleber strains. Methods ： Microscan autoscan4 auto - identified drug - resistance analyzor for bacteria was adopt to determine drugresistance according to the standard made by NCCLS. Results ： The infection rate of P. kleber in infants aged from 1 to 30 days and from 1 to 12 months was 20. 9% and 62.3% , respectively. The drug sensitivity of 196 P. kleber strains for the common 20 anti - biotins followed as 98.0% for Imipenem; 87.8% for Tobramycin; 86. 2% for Amikacin; 84. 7% for Pip/Tazo; 82. 1% for Gentamicin; 70.9% for Cefoxitin; 68.4% for Ciprofloxacin; 67. 9% for Trimeth/Sulfa and 56. 6% -94. 9% for the 12 other ones. Conclusion： The period of woman＇s pregnancy and health - care work for infants should be strengthened in woman - child Hospital due to weak cellular and humoral immunity of infants. The risk of P. kleber＇s drug - resistance should be a loud wake - up call for associated workers.