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AMPA受体GluR2在糖尿病大鼠海马中的表达

Expression of AMPA GluR2 in the Hippocampus of Diabetic Rats
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摘要 目的检测糖尿病大鼠海马中G luR2的表达,观察海马的病理变化。方法将24只W istar大鼠随机分成两组,对照组与糖尿病组各12只。糖尿病组用STZ制模,12周后,取脑应用免疫组化及图像分析技术检测海马中G luR2的表达。结果糖尿病组大鼠海马CA3区G luR2的表达较正常组减少(P<0.01)。结论钙离子可能在糖尿病大鼠海马的病理改变中发挥了重要作用。 Objective To measure the expression of AMPA GluR2 in the hippocampus of rats with diabetes mellitus（DM） ,and to abserve the pathological changes of hippocampus in DM. Methods 24 Wistar rats were randomly divided into two groups： 12 rats as the control group and 12 rats as the STZ DM group. 12 weeks later, the immunohistochemical methods and image-analysis were used to detect the expression of GluR2 in the hippocampus. Results Expression of GluR2 in CA3 area of hippocampus in DM group was less than normal group （ P 〈 0.01 ）. Conclusion Ca^2＋ may related with changes of hippocampus in DM.
作者 陈拥彬 刘德明
机构地区 咸宁学院医学院人体解剖学教研室 华中科技大学同济医学院组织胚胎学教研室
出处 《咸宁学院学报（医学版）》 2006年第3期207-209,共3页 Journal of Xianning Univarsity(medical Sciences)
关键词 糖尿病 海马 GLUR2 大鼠 Diabetes Hippocampus GluR2 Rat
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

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二级参考文献13

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咸宁学院学报（医学版）
2006年 第3期

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