摘要
目的研究判定宫颈癌患者预后的分子生物学指标。方法通过免疫组织化学方法观察人错配修复基因2(hMSH2)、细胞增殖核抗原(Ki-67)在宫颈鳞癌、腺癌组织中的表达。结果在宫颈癌组织中hMSH2、Ki-67阳性表达率高于正常宫颈组织(均P<0.01);hMSH2高表达与宫颈癌淋巴结转移、癌细胞分化程度密切相关(均P<0.05);hM-SH2表达阳性者Ki-67表达强度明显高于hMSH2表达阴性者(P<0.05)。结论hMSH2、Ki-67可能参与宫颈癌的发生、发展及转移过程,hMSH2在宫颈癌中的过表达与细胞增殖密切相关。
Objective To study the molecular biological criterion evaluating the prognosis of patients with cervical cancer. Methods The expression of hMSH2 and Ki-67 was detected in squamous cell carcinoma and adenocarcinoma by using immunohistochemical staining. Results The expression of hMSH2 and Ki-67 in cancer cells was significantly higher than that in control group （P〈0.01）. Overexpression of hMSH2 in cervical carcinoma was related to lymph node metastasis and differentiation degree （P〈0.05）. The expression of Ki-67 was significantly higher in the hMSH2-positive tumors than in the negative ones （P 〈0.05）. Conclusion The expression of hMSH2 and Ki-67 might play an important role in carcingensis, development and metastasis of cervical carcinoma. Its overexpression is also closely related with tumor cell proliferation.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2006年第3期339-342,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
