B7-H4在结直肠癌组织中表达的临床意义

Clinical significance of expression of B7-H4 in colon and rectal cancer tissues

目的:探讨T细胞共刺激分子B7家族成员B7-H4在结直肠癌发病中的作用,为临床诊断、治疗结直肠癌提供新的靶目标。方法:应用免疫组织化学染色检测40例结直肠癌患者手术标本中B7-H4的表达。结果:①B7-H4在结直肠癌组织中高表达(80.0%);②结直肠癌组织中B7-H4的表达与性别、年龄、组织学类型、病理分期、细胞分化和淋巴结转移均无相关性;③B7-H4阳性标本的肿瘤浸润性淋巴细胞(TILs)为25.10±14.46,明显低于B7-H4阴性标本中的TILs(38.23±18.33),P<0.01。结论:①B7-H4可成为结直肠癌诊断的指标;②结直肠癌组织中B7-H4的表达抑制了结直肠癌中TILs的数量,封闭结直肠癌中B7-H4有可能成为结直肠癌免疫治疗的新策略。

Objective： To investigate the role of B7-H4 in the development of colon and rectal cancer （CRC）. Method： The expression of B7-H4 in 40 excised colon and rectal tumors was evaluated immunohistochemiscally. Results： B7-H4 was high expressed （80.0%）in colon and rectal cancer. No relationship was found between the expression of B7-H4 and sex, age, histology type, pathology stage, cell differentiation, or lympha metastasis, However, significantly fewer TILs was identified in B7-H4-positive tumor specimens than in B7-H4-negative tumor specimens. Conclusion： ①B7-H4 may be a new marker of diagnosis for colon and rectal cancer;②These resuhs suggest that the expression of B7-H4 on tumor tissue may contribute to negative regulatory immunue responses against TILs in colon and rectal cancer. The blockade of B7-H4 in colon and rectal cancer might be one strategy to pursue for future immunotherapy in colon and rectal cancer.