芪菖治瘫口服液对脑缺血再灌注损伤大鼠脑细胞凋亡的影响

The Effect of Qichangzhitan Oral Liquid(芪菖治瘫口服液) on Apoptosis of Cerebral Cells in Rats with Cerebral Ischemia-Reperfusion Injury

目的观察芪菖治瘫口服液对脑缺血再灌注损伤大鼠脑细胞调亡的影响。方法利用先后夹闭大鼠双侧颈总动脉、基底动脉的方法制备大鼠脑缺血再灌注损伤模型,测定假手术对照组、模型对照组、各给药组大鼠各部位脑组织凋亡细胞数。结果各给药组凋亡细胞数均不同程度地低于模型对照组,有显著的统计差异。结论芪菖治瘫口服液具有减少细胞凋亡的作用。

Objective:To observe the effect of Qichangzhitan Oral Liquid(芪菖治瘫口服液) on apoptosis of cerebral cells in rats with ischemic-reperfusion injury.Methods:To make rat models with cerebral ischemia-reperfusion trauma by closing bliateral common carotid arteries and basilar arteries successively.Then,measured the number of apoptosis cerebral cells of rats of pseudo-surgical contrast groups,model contrast groups and medicine groups.Results:The numbers of apoptosis cerebral cells of each medicine groups are all less than model contrast groups in different degree,and it had statistic difference.Conclusion:Qichangzhitan Oral Liquid has the function of decreasing apoptosis of cerebral cells.