注射用泮托拉唑治疗上消化道出血的有效性和安全性的Meta分析

Meta-analysis of effectiveness and safety of intravenous pantoprazple for treating upper gastrointestinal hemorrhage

目的了解注射用泮托拉唑治疗上消化道出血的有效性和安全性差异。方法应用meta分析对19篇文献注射用泮托拉唑与其他抑制胃酸药物治疗上消化道出血的21项有效性研究和16项安全性研究进行同质性检验和合并效应量的估计。结果（1）同质性检验：有效性，x^2=14．6717，自由度为20；安全性，x^2=8．7235，自由度为15，两者P均大于0．05，具有同质性，可以合并结果。（2）合并效应量的估计：有效性，OR合并=3．5495，OR合并95％的可信区间为2．6219—4．8053。OR合并的检验：x^2=67．1900，P〈0．001；安全性，OR合并=0．4812，OR合并95％的可信区间为0．3191—0．7266。OR合并的检验：x^2=12．1781，P〈0．001。结论注射用泮托拉唑治疗上消化道出血的疗效总体优于对照组，且副作用较低。

Aim To compare the differences in the effectiveness and safety between intravenous pantoprazple and other drugs for treating upper gastrointestinal hemorrhage. Methods The effectiveness and safety between intravenous pantoprazple and other drugs for treating upper gastrointestinal hemorrhage were analyzed by Meta-analysis in homogeneity test and combined test. Result Homogeneity test showed that the cited studies of efficacy and safety were homogeneous with X^2 = 14.6717, X^2 = 8. 7235 ,P 〉 0.05 ,respectively. In combined test, the combined OR = 3. 5495, OR = 0.4812 and its 95% confidence interval was in 2. 6219 - 4. 8053,0. 3191 - 0.7266, respectively. Conclusion The effectiveness of intravenous pantoprazple in treating upper gastrointestinal hemorrhage is significantly superior to those of the medications used at present and the rate of side effects was low.