有关学习记忆的重组选择模型

Rearrangement and Selection Hypothesis of Learning and Memory

将学习记忆和免疫应答相比较，发现有一系列类似的特征。以免疫应答为参照，结合学习记忆的特征和生理学及心理学的有关实验，我们提出“重组选择”模型解释学习记忆的机制。重组分二个层次：１、基因重组。即在中枢神经系统发育的过程中，一组特异的基因经重组导致相应的神经元克隆化，而形成各种克隆，负责各种外界基本信息单位的识别和记忆。２、信息重组。通过学习，外界信息选择相应的克隆化的神经元，经神经网络将基本信息组成各种复杂的信息。不同的个体在不同的环境中受到不同的选择而形成不同的知识结构。知识不遗传的特征保证了后天最大限度的选择。本模型解释了人的大脑为什么能利用较少数基因编码无数信息。

As similar manifestations exist between both process of learning, memory and process of specific immune response, the similar mechanism may probably exist in both, Referring to traits of specific immune response and characteristics of learning and memory as well as associated experiments, we have now introduced “clonal selection” theory and proposed a rearrangement and selection model to explain mechanism of learning and memory on basis of our previous “Twice rearrangement” model. (1) Gene rearrangement :During development of the central nervous system, rearrangement of a set of genes like immunoglobin genes results in generation of neuron clones which are responsible for memory of various individual and basic foreign informations. (2) Information rearrangement: Through learning, foreign informations select relevant neuron clones and are rearranged into various complex informations via nervous network. Different individuals acquire different selection respectively in postnatal environment and have different knowledge structure. The nonhereditary trait of knowledge ensures postnatal selection to a maximum. The model try to explain why the central nervous system can adapt to needs of memory for countless foreign informations employing genes limited in number.