肿瘤患者院内真菌感染的临床分析

Nosocomial Fungus Infection in Malignant Tumor Patients:A Clinical Analysis

目的 了解我院肿瘤患者医院内真菌感染的临床特点，有效预防和控制医院真菌感染。方法 对2002年1月～2004年12月出院患者，真菌培养阳性病例进行回顾性分析。结果 感染发生率2．08％，319例医院真菌感染患者中，白色念珠菌最多占72．58％，其次是光滑念珠菌占11．29％；年龄〉60岁、抗生素的滥用、激素、放疗、化疗、侵入性操作、抗真菌治疗不规范等是真菌感染的危险因素。结论 要高度重视医院内真菌感染，加强真菌学的教育，规范抗生素应用，重视早期病原学检查。

OBJECTIVE To investigate the clinical features of and prevent and control the nosocomial fungus infection in the malignant tumor patients of our hospital. METHODS The fungus-cultured positive cases among the discharged patients from Jan 2002 to Dec 2004, were reviewed and analyzed. RESULTS The rate of nosocomial fungus infection was 2.08%. The incidence of Candida albicans infection was the highest （72.58 ~）, followed by C. glabrata （11.29%）. The causes of these infections were highly associated with risk factors such as age 〉60 years old, severe underlying disease, abuse application of antibiotics, hormones, immunosuppressors and radio- and chemotherapy, invasive operation, and so on. CONCLUSIONS It is important to find out nosocomial fungus infection earlier, and to treat it in time. We must strengthen the education about nosocomial fungus infection, apply the antibiotics regularly and rationally, and pay attention to result of culturing from the microbiological laboratory.