重组人干扰素α2a滴鼻剂抗病毒药效学研究

Research on Antiviral Effects of Recombinant Human Interferon(rhIFN) α2a Naristilla

为了检测干扰素滴鼻剂抗病毒药效作用,采用组织细胞培养法及建立流行性感冒动物模型,对不同浓度的干扰素滴鼻剂进行了体内外抗病毒药效学研究。结果显示:在体外有抑制流感病毒、呼吸道合胞病毒、副流感病毒、麻疹病毒、腺病毒、柯萨奇B3病毒的作用,对单纯疱疹病毒有部分抑制作用。在体内可有效抑制流感病毒所致的病毒性肺炎。可见,重组人干扰素α2a滴鼻剂在体内外均有较明显的抗呼吸道病毒的作用。

Detect antiviral effect of Interferon α2a naristilla. Apply tissue cell culture and establish flu animal animal model, so as to study the antiviral effect inside and outside the body of the Interferon α2a naristiUa by different density. Both in vivo and vitro Interferon α2a naristilla has the inhibition effect on Influenza virus, RS virus, Parain-fluenza virus, Measles virus, Adenovirns, Coxsackie virus B5 and has some inhibitory activity on the Labialis virus. It also can inhibit the viral pneumonia caused by influenza virus in the body effectively. Recombinant Human Interferon（rhIFN） α2a NaristiUa has evident resist Respirovirus effect.