平阳霉素磁控缓释微球的特性检测

Characteristics Test of Sustained release Gelatin PYM Magnetic Microspheres

用紫外分光光度法和原子吸收分光光度法，对自制的平阳霉素磁性明胶微球中的平阳霉素及Ｆｅ３Ｏ４的含量进行了检测，平阳霉素的含量为４５μｇ／ｍｇ，Ｆｅ３Ｏ４的含量为３１０μｇ／ｍｇ。用自行设计的释放速率测量器测量了平阳霉素磁性明胶微球在３７℃水溶液中药物的释放速率，平阳霉素释放完全达３ｈ以上，磁性微球具有缓释作用。

Ultraviolet spectrometry and atomic absorption spectrometry were used to measure the contents of PYM and Fe 3O 4 in gelatin PYM magnetic microspheres. The results show that the PYM content was 45 μg in 1mg of the microspheres and Fe 3O 4 310 μg. Using self designed release rate instrument, authors found that PYM could be released from the microspheres in water suspension at 37℃ for more than 3 hours without change of the shape observed under microscope.