胃癌组织中人表皮生长因子含量和临床意义

CONTENT OF HUMAN EPIDERMAL GROWTH FACTOR IN GASTRIC CARCINOMA TISSUE AND ITS CLINIAL SIGNIFICANCE

检测人表皮生长因子（ｈＥＧＦ）在胃癌组织中的含量，初步探讨其临床意义。用放射免疫分析法测定５２例胃癌切除标本和１８例正常胃粘膜组织中ｈＥＧＦ的含量。结果：对照组为１．４９±０．９５ｎｇ／ｇ湿重，胃癌组织为４．２９±２．３５ｎｇ／ｇ湿重，差异显著（Ｐ＜０．０１）。在胃癌组织中，ｈＥＧＦ含量进展期高于早期，弥漫型高于肠型，淋巴结转移阳性者高于阴性者，近期随访发现胃癌患者死亡组的ｈＥＧＦ含量较高。结论：胃癌组织可产生过量的ｈＥＧＦ，并与肿瘤浸润、组织分化程度、淋巴结转移等相关，提示胃癌组织ｈＥＧＦ测定可作为判断胃癌生物学行为及了解患者预后的指标。

PURPOSE The content of human epidermal growth factor(hEGF)in gastric carcinoma tissue and its clinical significance. METHODS The content of hEGF was determined with radioimmunoassay.In a total of 70 gastric specimens comprising 18 normal gastric mucosa and 52 carcinomas. RESULTS The average content of hEGF(4.29±2.30 ng/g wet weight) of gastric carcinomas was significantly higher than that(1.49±0.95 ng/g wet weight) of gastric mucosa(P<0.01). The hEGF content of gastric carcinomas showed a significant correlation with invasion, differentiation and lymph node metastasis.Futhermore,patients with higher hEGF content(>5ng/g wet weight) had a much worse prognosis than those with lower hEGF content.CONCLUSIONS These results suggest that hEGF level in gastric carcinoma is a valuable marker for estimation of biological behavior of the tumor and its prognosis.