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嗜酸性粒细胞趋化因子与鼻变应性疾病 被引量：4

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摘要 嗜酸性粒细胞趋化因子,目前发现有三种,即eotaxin-1,eotaxin-2,eotaxin-3。它们功能相似,均能通过结合共同的受体CCR3发挥功能。尤其对嗜酸性粒细胞具有强大的选择性激活作用,在鼻变应性疾病发生发展中有着重要意义。
作者 洪娟 黄建民
机构地区 福建医科大学附属协和医院耳鼻咽喉科
出处 《国际耳鼻咽喉头颈外科杂志》 2006年第4期251-254,共4页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 趋化因子 嗜酸细胞(Chemotactic Factors Eosinophil) 鼻炎 变应性 常年性(Rhinitis Allergic Perennial)
分类号 R765 [医药卫生—耳鼻咽喉科]
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参考文献19

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  • 2Matsukura S,Stellato C,Steve N,et al.Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism.Am J Respir Cell Mol Biol,2001,24(7):755-761.
  • 3RothenbForssmannU,UguccioniM,LoetscherP,etalEotaxin-2,anovel CC chemokine that is selective for the chemokine receptor CCR3,and acts like eotaxin on human eosinophil and basophil leukocytes.J ExpMed,1997,185(12):2171-2176.
  • 4Kitaura M,Suzuki N,Imai T,et al.Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3.J Biol Chem,1999,274(39):27975-27980.
  • 5Lezcano-MezaD,Davila-DavilaB,Vega-MirandaA,et al.Interleukin (IL) -4 and to a lesser extent either IL-13 or interferon-gamma regulate the production of eotaxin-2/CCL24 in nasal polyps.Allergy,2003,58 (10):1011-1017.
  • 6Banwell ME,Tolley NS,Williams TJ,et al.Regulation of human eotaxin-3/CCL26 expression:modulation by cytokines and glucocorticoids.Cytokine,2002,17(6):317-323.
  • 7Abonyo BO,Alexander MS,Heiman AS.Autoregulation of CCL26 synthesis and secretion in A549 cells:a possible mechanism by which alveolar epithelial cells modulate airway inflammation.Am J Physiol Lung Cell Mol Physiol,2005,289 (3):L478-L488.
  • 8Bandeira-Melo C,Herbst A,Weller PF.Eotaxins contributing to the diversity of eosinophil recruitment and activation.Am J Respir Cell Mol Biol,2001,24 (6):653-657.
  • 9Terada N,Hamano N,Kim W J,et al.The Kinetics of allergen-induced eotaxin level in nasal lavage fluid.its key role in eosinophil recruitment in nasal mucosa.Am J Respir Crit Care Med,2001,164 (4):575-579.
  • 10Petkovic V,Moghini C,Paoletti S,et al.Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5:a human chemokine with a regulatory role.J Biol Chem,2004,279 (22):23357-23363.

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国际耳鼻咽喉头颈外科杂志
2006年 第4期

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