正常大鼠视网膜感光细胞超微结构在视觉发育关键期中的变化

Ultrastructural changes of rat retinal sensitive cell in critical period of visual development

目的观察出生后大鼠视网膜感光细胞超微结构在视觉发育关键期（7～30d）中的变化特点。方法10只正常健康Wistar大鼠，8只为新生大鼠，2只为成年大鼠。新生大鼠随机分为4组，每组2只，正常饲养，分别于出生后0、15、20、25d摘取眼球进行视网膜电镜观察。2只成年大鼠亦进行视网膜电镜观察。结果出生后0d大鼠，视网膜感光细胞超微结构幼稚且细胞层次不清，关键期内感光细胞的细胞器逐步丰富发育成熟，层次渐显清晰。结论大鼠视网膜感光细胞在视觉发育关键期内逐渐发育、成熟。

Objective To observe the changes of retinal sensitive cellular uhrastructure of rats in critical period of visual development. Methods Ten normal healthy Wistar rats were chosen, eight of which were neonatal rats and two were mature rats. The eight neonatal rats were randomized into four groups （n = 2 in each group） and respectively sacrificed on postborn day 0, 15, 20, 25. The eyeballs of the neonatal rats and the mature rats were resected and the retinas were observed by electron microscope. Results The rat retinal sensitive cdlular ultrastructure on postborn day 0 was immature and the cdlular arrangement was not clear. The organdie of sensitive cell in critical period developed mature gradually and the arrangement of them was very clear. Conclusion The retinal sensitive cell of rats develops and matures gradually in critical period.