尿激酶治疗高血压性脑室内出血的疗效

Treatment of hypertensive intraventricular hemorrhage by urokinase

目的探讨尿激酶治疗高血压性脑室内出血的可行性、有效性和安全性。方法将患者分为尿激酶治疗组39例与单纯引流组30例,通过动态CT扫描和ADL评分,比较2组脑室内血块的消退时间和患者预后。结果尿激酶治疗组脑室内血块消退时间明显短于单纯引流组(P=0.030),预后也优于单纯引流组(P=0.029)。结论尿激酶治疗高血压性脑室内出血简单、安全、有效。

Objective To di with hypertensive intraventricular scuss the feasibility, efficiency and safety of urokinase application in patients hemorrhage. Methods Sixty-nine patients were included, 30 treated with ventricular drainage alone and 39 receiving adjunctive intraventricular urokinase. CT images and ADL scores were compared between the two groups. Results The intraventricular thrombolysis with urokinase significantly hastened the resolution of intraventricular blood clots as compared with ventricular drainage alone （ P = 0.030）, with better outcome （ P = 0.029）. Conclusion Urokinase application is a simple, effective, and safe in man- aging hypertensive intraventricular hemorrhage.