定量组织速度成像评价阿霉素致兔早期心脏毒性左心室收缩功能影响的研究

Effects of left ventricular systolic function in rabbits with early adriamycin-induced myocardial damage using quantitative tissue velocity imaging

目的探讨定量组织速度成像(QTVI)技术评价阿霉素早期心脏毒性左室心肌收缩功能的价值。方法42只兔分成4组:B组10只,每周静脉注射阿霉素2mg/kg,注射2周;C组10只,同样方法给予阿霉素4周;D组12只同样方法给予阿霉素8周;A组(对照组)10只,注射同等剂量生理盐水8周。12周后对4组兔心脏进行常规超声测量及QTVI参数测定,包括:二尖瓣环收缩期峰值速度(Vs)、收缩期加速度(a)等。结果C组和D组二尖瓣环平均Vs和a明显减低(P<0.01)。常规超声参数D组与A组比较有明显差别(P<0.01)。D组各参数与C组比较有明显差别(P<0.05或P<0.01)。病理结果从B组到D组的心肌损害程度逐渐加重。结论定量组织速度成像技术可无创有效地评价阿霉素早期心脏毒性左室心肌收缩功能的变化。

Objective To evaluate the experimental value of quantitative tissue velocity imaging （QTVI） in assessment of left ventricular systolic function with early adriamycin-induced myocardial damage in rabbits. Methods Fourty-two rabbits were divided into four groups （10, 10, 10 and 12 rabbits in groups A, B, C and D respectively）, and Rabbits in groups B, C and D were given 2mg/kg body weight of adriamycin intravenously once a week for 2 weeks, 4 weeks and 8 weeks. Ten control rabbits received 2 ml/kg body weight of normal saline once a week for 8 weeks. After 12 weeks, peak velocity during systole （Vs） and systolic acceleration （a） at the mitral annulus were measured by QTVI and conventional echographic parameters were also obtained. Results Average Vs and a were significantly lower in C and D groups than those of the control group （P〈0.01）. The conventional echographic parameters of the group D were significantly different with those of the group A （P〈0.01）. The parameters of the group D were significantly different with those of the group C （P〈0.05 or P〈 0.01）. The pathological examination demonstrated that the damages increased from groups B, C to group D. Conclusion QTVI is a noninvasive and valuable method to assess the changes of left ventricular systolic function with early adriamycininduced myocardial damage in rabbits.