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树突状细胞在系统性红斑狼疮免疫发病中的作用 被引量：3

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摘要 系统性红斑狼疮（systemic lupus erythematosus，SEE）是一种以机体内广泛的免疫异常和多器官功能损伤为特征的自身免疫性疾病，其临床表现多种多样，病情往往呈缓解和恶化交替进行。自身抗体形成和免疫复合物沉积所致的组织损伤是该病的特点之一。其中。大多数的自身抗体是针对DNA和核小体的，这是SEE的一大免疫学特征，由此提出一种假说：抗原递呈细胞（APC）对凋亡细胞不恰当的处理导致了SEE的发生。而树突状细胞（dendritic cell，DC）是一类最有效的APC，无论在体内外它都可以激活未致敏T淋巴细胞。更重要的是，DC能高效地摄取、处理内源性和外源性抗原肽，并递呈给T淋巴细胞．因此DC可能在SEE发病中有重要的作用。本文就近几年来的研究进展作一综述。
作者 邓珊 胡大伟
机构地区 上海交通大学医学院附属仁济医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 2006年第7期435-437,共3页 Chinese Journal of Rheumatology
关键词 自身免疫性疾病 系统性红斑狼疮 树突状细胞 erythematosus 发病 抗原递呈细胞 多器官功能损伤 免疫复合物沉积 T淋巴细胞 lupus
分类号 R593.241 [医药卫生—内科学]
  • 相关文献

参考文献17

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共引文献2

同被引文献21

  • 1杜隽铭,全志伟,单根法.树突状细胞与移植免疫[J].肝脏,2004,9(2):132-133. 被引量：1
  • 2孙景武,孙世波.树突状细胞与移植免疫耐受[J].实用医学杂志,2005,21(5):546-548. 被引量：4
  • 3高苏俊,季晓辉.树突状细胞研究新突破——诱导免疫耐受[J].医学综述,2006,12(15):905-907. 被引量：2
  • 4LI Wei-min,LIU Wei,GAO Cheng,ZHOU Bao-guo,YANG Shu-sen,WANG Zheng,ZHANG Rui-hong,GAN Run-tao,KONG Yi-hui,LI Yue.Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats[J].Chinese Medical Journal,2006(19):1646-1652. 被引量：13
  • 5Tamura T, Tailor P, Yamaoka K, et al. IFN regulatory factor-4 and-8 guvem dendritic cell subset development and their functional diversity [J]. J Immunol,2005,174(5) :2573 -2581.
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引证文献3

二级引证文献6

中华风湿病学杂志
2006年 第7期

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