摘要
目的探讨胶原诱导性关节炎(collagen-induced arthritis,CIA)大鼠滑膜组织膜联蛋白-1 (Annexin-1)的表达及意义。方法采用Western blot法检测模型组及正常组大鼠在不同时间点滑膜组织Annexin-1的表达,运用ImageTool 3．0灰度扫描软件对结果进行半定量分析。结果正常组及模型组皆表达Annexin-1。模型组Annexin-l表达在25、35和45d水平递减,45d与25d相比,差异有统计学意义(P＜0．05)。45d Annexin-1表达明显低于正常组(P＜0．05)。结论CIA大鼠滑膜组织Annexin-1表达下调。
Objective To study the Annexin-1 expression in the synovium of collagen-induced arthritis （CIA） rat. Methods Annexin-1 expression in CIA group and normal group during the experiment was tested by Western blot and semi-quantification of gray scale. Results Annexin-1 was expressed in both normal anal CIA group. Annexin-1 expression in the experimental group declined at the 25, 35, 45 d, its expression at the 45 d was significantly lower than that in the normal group （P〈0.05）. Conclusion Annexin-1 expression in the synovium of CIA rat is downregnlated. This is probablely the mechanism of rheumatoid arthritis pathogenesis.
出处
《中华风湿病学杂志》
CAS
CSCD
2006年第7期410-412,i0003,共4页
Chinese Journal of Rheumatology
基金
国家自然科学基金(30371833)
