巨噬细胞移动抑制因子在大肠癌中的表达及其意义

Expression of macrophage migration inhibition factor in colorectal carcinoma tissue

目的观察巨噬细胞移动抑制因子(MIF)在大肠癌中的表达及其意义。方法应用免疫组化技术对43例大肠癌及10例正常大肠组织中的MIF蛋白表达进行研究。结果大肠癌组织中的MIF表达率为65.1%(28/43),明显高于正常大肠组织0.0%(0/10),二者之间差异有统计学意义(P<0.01)。MIF表达与大肠癌组织学类型及Dukes分期无明显相关(P>0 05),但与大肠癌分化程度、淋巴结转移呈显著相关(P<0.05)。结论MIF在大肠癌中呈过度表达,与淋巴结转移、分化程度有密切关系。提示MIF可能参与了大肠癌的发生与发展。检测大肠癌组织中MIF表达有助于预测患者预后。

Objective To observe the expression of macrophage migration inhibition factor （MIF） in colorectal carcinoma tissue and to analyze the relationship between MIF expression and clinical manifestations. Methods MIF expression in colorectal carcinoma and normal colorectal tissues were studied by immunohistochemical method. Results The positivity rates of MIF in colorectal carcinoma and normal tissue were respectively 65.1 %（28/43）and 0.0 % （0/10）. MIF was expressed more obviously in colorectal carcinoma tissues than in normal tissues（P〈0.01）. MIF expression was found to relate to lymph node metastasis and the degree of cell differentiation of colorectal carcinoma（P〈0.05 ）, but not to the clinical stages and histological type （P〉 0 05 ）. Conclusion Overexpression of MIF in colorectal carcinoma,is closely related to lymph node metastasis and the degree of cell differentiation of colorectal carcinoma. It might be related to the pathogenesis of colorectal carcinoma,and also may be a prognostic marker.