丹蛭降糖胶囊对胰岛素抵抗大鼠抵抗素的影响

Effect of Danzhijiangtang Capsule on Serum Resistin Level in IR Rats

目的观察丹蛭降糖胶囊对小剂量链脲佐菌素加高热量饲料诱导的胰岛素抵抗模型大鼠血清抵抗素含量的影响。方法雄性Wistar大鼠随机分为空白组、模型组、中药低剂量组、中药高剂量组。空白组喂以普通饲料,模型组与各治疗组注射小剂量链脲佐菌素并喂以高热量饲料,常规测定各组大鼠治疗前后的体重、空腹血糖和治疗后各组大鼠的空腹血清胰岛素水平,计算胰岛素敏感性指数,测定各组血脂、血清抵抗素水平。结果丹蛭降糖胶囊能有效地减轻模型大鼠体重,明显降低大鼠的空腹血糖和空腹胰岛素水平,改善脂代谢紊乱状况,提高胰岛素敏感指数,降低血清抵抗素水平(P<0.05)。结论丹蛭降糖胶囊对胰岛素抵抗大鼠有显著的改善作用,其机制可能与降低血清抵抗素水平有关。

Objective To investigate the effect of Danzhijiangtang Capsule on serum resistin level m insulin resistance （IR） rats induced by low dose of streptozotocin （STZ） and high calorie food. Methods Male Wistar rats were randomly divided into normal group, model group, low dose and high dose of Danzhijiangtang capsule treating group. The rats of normal group were fed with common food while the others with high calorie food and injected with low dose of STZ. The weight, fasting blood glucose （FBG）, fasting insulin （Fins）, blood fat, resistin level of all rats were measured, and insulin sensitivity index （ISI） was calculated accordingly. Results Danzhijiangtang capsule could reduce body weight of IR rats. According to the results of biochemical indicator detection, Danzhijiangtang capsule could reduce FBG and Fins level, improve blood fat condition, enhance ISI effectively and decrease resistin level （P〈0.05）. Conclusion Danzhijiangtang capsule can ameliorate IR condition of the model rats and .its mechanism is probably related to its effect of decreasing resistin level.