生姜水提物和内毒素诱导脑缺血耐受的比较研究

Comparative Study on the Capability of Inducing Cerebral Ischemia Tolerance of Zingibers Aquueous Extract and Endotoxin

目的观察生姜水提物诱导脑缺血耐受能力。方法采用SD大鼠大脑中动脉阻塞模型,比较生姜水提物预处理后模型动物神经功能缺损程度和脑梗死体积的变化。结果生姜水提物预处理组与对照组大脑中动脉阻塞模型大鼠脑梗死体积分别为(120.6±21.57)mm3和(155.9±21.34)mm3,P<0.01;生姜水提物预处理组与对照组大脑中动脉阻塞模型大鼠再灌注24h后神经功能缺损Zealonga评分法评分分别为(1.7±0.68)分和(2.4±0.70)分,P=0.056。结论生姜水提物可在一定程度上增强大鼠脑缺血耐受能力。

Objective To observe the capability of inducing cerebral ischemia tolerance of Zingibers aqueous extract. Method Comparing the volume of cerebral infarction and the level of neurologic impairment in the model of middle cerebral artery occlusion in rats. Result The volume of cerebral infarction is （120.6±21.57}mm^3 and （155.9±21.34）mm^3 in the preconditioning group by Zingibers aqueous extract and control group respectively （P〈0.01）. The level of neurologic impairment is 1.7±0.68 and 2.4±0.70 in the preconditioning group by Zingibers aqueous extract and control group respectively （P=0.056）. Conclusion Zingibers aqueous extract can induce cerebral ischemia tolerance to some extent in rats.