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Clara细胞、Clara细胞分泌蛋白在哮喘发病机制中的作用 被引量：3

Role of Clara Cell and Clara Cell Secretory Protein in the Pathogenesy of Asthma
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摘要 Clara细胞是一种无纤毛上皮细胞,主要分布于终末细支气管和呼吸性细支气管上皮;Clara细胞具有活跃的增殖分化特性,参与支气管上皮损伤的修复过程。Clara细胞分泌蛋白(CCSP)是Clara细胞最主要的分泌产物,具有抗炎、抗纤维化的生物学特性。而支气管哮喘是一种慢性呼吸道炎症性疾病,本文就近年来Clara细胞、CCSP与哮喘发病机制关系的研究进展简要综述。 Clara cells are epithelial cells without cilia located maily in the terminal bronchioles and the respiratory bronchioles. Clara ceils have the characters of proliferation and differentiation, participating in reparative process of bronchial epithelium injury . Clara cell secretory protein（CCSP） is the predominant product from Clara cells, which posses biological properties including anti-inflammation and anti-fibrosis. Bronchial asthma is a chronic inflammatory disorder. The brief review outlines the relationship between Clara cell, CCSP and the pathogenic mechanism of asthma recently.
作者 温志红 农光民
机构地区 广西壮族自治区人民医院儿科 广西医科大学第一附属医院儿科
出处 《医学综述》 2006年第13期769-770,共2页 Medical Recapitulate
基金 广西科学基金项目(桂科青0447017)
关键词 哮喘 儿童 CLARA细胞 CLARA细胞分泌蛋白 Asthma Children Clara cells Clara cell secretory protein
分类号 R725.6 [医药卫生—儿科] R562.25 [医药卫生—呼吸系统]
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参考文献20

  • 1Boers JE, Ambergen AW, Thunnissen FB. Number and proliferation of Clara cells in normal human airway epithelium [J]. Am J Respir Crircare Med, 1999,159(5 Pt 1) : 1585-1591.
  • 2Stripp BR, Reynolds SD, Boe IM, et al. Clara cell secretory protein deficiency alters Clara cell secretory apparatus and the protein composition of airway lining fluid [J]. Am J Respir Cell Mol Biol, 2002, 27(2) : 170-178.
  • 3Fehrenbach H, Fehrenbach A, Pan T, et al. Keratinocyte growth factor induced proliferation of rat airway epithelium is restricted to Clara cells in vivo[J] .Eur Respir J,2002,20(5) :1185-1197.
  • 4Singh G, Katyal SL. Clara cells and 10 kD protein(CC10)[J]. Am J Respir Cell Mol Biol, 1997,17(2) : 141-143.
  • 5Hohlfeld J, Fabel H, Harem H. The role of pulmonary surfactant in obstructive airways disease[J]. Eurp Respir J, 1997,10(2) :482-491.
  • 6Singh G, Katyal SL. Clara cell proteins [J]. Ann NY Acad Sci, 2000,923 : 43-58.
  • 7Shijubo N, Itoh Y, Yamaguchi T, et al. Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma[ J]. Lung, 1999,177(1) :45-52.
  • 8Hay JG, Danel C, Chu CS, et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease[J]. Am J Physiol, 1995,268(4 Pt 1):L565-575.
  • 9Yoshikawa S, Miyahara T, Reynolds SD, et al. Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator induced lung injury in mice[ J]. J Appl Physiol, 2005,98 (4) : 1264-1271.
  • 10Johnston CJ, Mango GW, Finkelstein J-N, et al. Altered pulmonary responseto hyperoxia in Clara cell secretory protein deficient mice[J]. Am J Respir Cell Mol Biol, 1997,17(2) : 147-155.

二级参考文献14

  • 1Hermans C, Bernard A. Lung epithelium- specific proteins: characteristics and potential applications as markers[J ]. Am J Respir Crit Care Med, 1999,159(2) :646 - 678.
  • 2Mao XQ, Shirakawa T, Kawai M, et al. Association between asthma and an intragenic variant of CC16 on chromosome 11q13 [J ]. Clin Genet, 1998,53(1) :54 - 56.
  • 3Laing IA, Hermans C, Bernard A, et al. Association between plasma CC16 levels, the A38G polymorphism, and asthma[J ]. Am J Respir Crit Care Med ,2000,161( 1 ): 124 - 127.
  • 4Broeckaert F, Bernard A. Clara cell secretory protein (CC16 ): characteristics and perspectives as lung peripheral biomarker[J ]. Clin Exp Allergy,2000,30(4) :469 - 475.
  • 5Saadat M, Saadat I, Saboori Z, et al. Combination of CC16, GSTM1,and GSTTI genetic polymorphisms is associated with asthma[J ]. J Allergy Clin Immunol, 2004,113 (5): 996 - 998.
  • 6Johnston CJ, Mango GW, Finkelstein JN, et al. Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice[J]. Am J Respir Cell Mol Biol , 1997,17(2): 147 - 155.
  • 7Shijubo N, Itoh Y, Yamaguchi T, et al. Clara cell protein - positive epithelial cells are reduced in small airways of asthmatics[J ]. Am J Respir Crit Care Med , 1999,160(3) :930 - 933.
  • 8Lensmar C, Nord M, Gudmundsson GH, et al. Decreased pulmonary levels of the anti - inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics[J ]. Cell Mol Life Sci,2000,57(6): 976 - 981.
  • 9Yoshikawa S, Miyahara T, Reynolds SD, et al. Clara cell secretory protein and phospholipase A2 activity modulate acute ventilatorinduced lung injury in mice [J ]. J Appl Physiol, 2005, 98 (4):1264 - 1271.
  • 10Reader JR,Tepper JS, Schelegle ES, et al. Pathogenesis of mucous cell metaplasia in a murine asthma model[J ]. Am J Pathol, 2003,162 (6): 2069 - 2078.

共引文献9

同被引文献42

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二级引证文献6

医学综述
2006年 第13期

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