表皮生长因子受体在AngⅡ促心肌血管平滑肌细胞增殖中的作用

Advance in Research of Epidermal Growth Factor Receptors in Cardiac Muscle Cells and Vascular Smooth Muscle Cells Proliferation Promoted by Ang Ⅱ

表皮生长因子受体是受体酪氨酸激酶超家族中的一员,是细胞生长、分化和存活的重要调节因子,其作为中心点将AngⅡ与酪氨酸激酶通路连接起来,促使了心肌、血管平滑肌细胞的增殖重构,导致了某些心血管疾病的发生、发展。

Epidermal growth factor receptor is a member of receptor-tyrosin kinase superfamily and an important regulator in celI growth , differentiation and survival. It links Ang Ⅱ and tyrosin kinase path as a centre and promotes proliferation and remodling of cardiac muscle and vascular smooth muscle , which leads to the genesis and development of some cardiovascular disease.