肝硬化腹水合并自发性细菌性腹膜炎的研究

Research Advancement of Cirrhosis Ascitic Fluids Componded Spontaneous Bacterial Peritonitis

自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)是肝炎后肝硬化的常见并发症,其发病原因可能与宿主防御功能减弱、合并门脉高压、门体分流、肠道细菌移位和感染机会增多等因素有关。SBP腹水中相关因子(TNF-α,IL-1β,IL-6,IL-8等)与疾病的关系日益受到重视,腹水的检测对SBP的诊断有重要的价值,腹水的治疗也从多方面进行研究,抗菌治疗,生物治疗,中药治疗有了很大的进展。本文对SBP的发病机制、相关因子、检测方法、治疗的研究进展予以综述及展望未来。

Spontaneous bacterial peritonitis（SBP） is a common complication of posthepatitic cirrhotis. Its occurrence may be relate to host defense function decreseence, complicated portal hypertension, port-body shunting, bacterial translocation from intestine, high chance of infection and so on . The relationship between cytokines（TNF-α, IL-1β, IL-6, IL-8） in ascitic fluid and spontaneous bacterial peritonitis are attracting more and more attention . Detecting ascitic fluid is important in diagnosis of SBP.The therapy of ascitic fluid should be carried from many aspects, in which the therapy of antibiotic and Chinese herb and biotherapy have a big advancement. In this review, we discuss the progress in many aspects including its pathogenesis , related factors , detection method and therapy and prospect.