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英利昔单抗在消化系统疾病中的应用状况及前景 被引量:4

Evaluation of the Use of Infliximab for the Treatment of the Diseases of Digestive System
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摘要 目的:评价英利昔单抗在消化系统相关疾病治疗中的疗效和安全性。方法:收集国外相关文献进行综述、分析。结果及结论:英利昔单抗作为新一代的抗炎药通过中和TNF-α的生物学效应而发挥抗炎作用。对于克罗恩病、溃疡性结肠炎、酒精性肝病等消化系统疾病都有较好疗效,且在推荐的治疗范围内安全性良好。 OBJECTIVE : To evaluate the efficacy and the safety of infliximab for the treatment of the diseases of digestive system. METHODS: To collect pertinent literatures at abroad for an analysis. RESULTS & CONCLUSION: As a new generation anti - inflammatory drug, infliximab acts as anti - inflammatory action by neutralizing biological effect of TNF - α. It has fairly good efficacy in Crohn' s disease, ulcerative colitis, alcoholic liver disease and other diseases of digestive system with good safety within recommended treatment area.
作者 陈垦
出处 《中国医院用药评价与分析》 2006年第3期151-153,共3页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 英利昔单抗 TNF—α 临床评价 安全性 infliximab TNF- α clinical evaluation safety
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参考文献16

  • 1Ten hove T,Van Montfrans C,Pepelenbosch MP,et al.Infliximab treatment induces apoptosis of lamina propria T lymphocytes in crohn' s disease[J].Gut,2002,50 (2):206.
  • 2Targan SR,Hanauer SB,van Deventer SJ,et al.A shortterm study of chimeric monoclonal antibody cA2 to tumour necrosis factor alpha for crohn' s disease.Crohn' s Disease cA2 Study Group[J].N Engl J Med,1997,337(15):1029.
  • 3Topstad DR,Panaccione R,Heine JA,et al.Combined seton placement,infliximab infusion,and maintenance immunosup-pressives improve healing rate in fistulizing anorectal Crohn' s disease:a single center experience[J].Dis Colon Rectum,2003,46(5):577.
  • 4Tsujikawa T,Nezu R,Andoh A,et al.Infliximab as a possible treatment for the hemorrhagic type of Crohn' s disease[J].J Gastroenterol,2004,39(3):284.
  • 5Tsukada Y,Nakamura T,Iimura M,et al.Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis[J].Am J Gastroenterol,2002,97 (11):2 820.
  • 6Sands BE,Tremaine W J,Sandborn W J,et al.Infliximab in the treatment of severe,steroid-refractory ulcerative colitis:a pilot study[J],Inflamm Bowel Dis,2001,7(2):83.
  • 7Kugathasan S,Dubinsky MC,Keljo D,et al.Severe Colitis in Children[J].J Pediatr Gastroenterol,2005,41 (4):375.
  • 8Tilg H,Jalan R,Kaser A,et al.Anti-tumor necrosis factor -alpha monoclonal antibody therapy in severe alcoholic hepatitis[J].J Hepatol,2003,38(4):419.
  • 9Mookerjee RP,Sen S,Davies NA,et al.Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis[J].Gut,2003,52(8):1 182.
  • 10Campbell S,Ghosh S.Infliximab therapy for Crohn's disease in the presence of chronic hepatitis C infection[J].Eur J Gastroenterol Hepatol,2001,13(2):191.

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