阿立派唑与利培酮治疗精神分裂症的对照研究

A Control Study on Aripiprazole and Risperidone in the Treatment of Schizophrenia.

目的比较阿立派唑与利培酮治疗精神分裂症的疗效和安全性。方法对符合CCM D-3精神分裂症诊断标准的90例患者,随机分为2组分别给予阿立派唑和利培酮治疗共8周。采用PAN SS和TESS量表评分。结果治疗8周后阿立派唑组和利培酮组的显效率分别为64.4%和71.1%,差异无显著性。两组治疗后各时点PAN SS总分及各因子分也无显著性差异(P>0.05)。阿立派唑组的主要副反应为失眠,焦虑,头昏,头痛,静坐不能,肌张力增高,恶心,厌食。与利培酮组相当,无显著性差异(P>0.05)。而月经紊乱显著低于利培酮组。结论阿立派唑和利培酮对精神分裂症疗效相当,副反应轻,均为疗效好、安全性高的抗精神病药。

Objective To compare efficacy and safety of aripiprazole and risperidone in the treatment of schizophrenia. Methods 90 adult patients were recruited in this study. All the cases are diagnosed as schizophrenia in accordance with the CCMD- 3 diagnosis standard and randomized into two groups which were treated with aripiprazole or risperidone for 8 weeks. The Positive and Negative Syndrome Scale （PANSS） and Treatment Emergent Side effect Scale （TESS） were used to evaluate efficacy and adverse effects respectively before and at the ends of 2, 4, 8 weeks treatment. Results The significant effective rates of Aripiprazole was 64.4% after 8 weeks while that was 71.1% in Risperidal group. There was no significant difference between the two groups＇ efficiency rates （P〉0.05）. There were no significant differences between both groups in each total scores of PANSS and each factor score at pre-treatment, 2, 4, 8 weeks after treatment （P〉0. 05）. The chief adverse effects of aripiprazole were insomnia, anxiety, dizziness, headache, akathisia or muscular tension increase and nausea or anorexia. There was no significant difference between the two groups＇ side effect. Menstrual. disorder in arlpiprazole group was lower then that in risperidal group. Conclusion The results suggest that aripiprazole and risperidal have the similar effectives in the treatment of schizophrenia and fewer side effects in them, They are efficient and safe antipsychotic drugs in treatment of schizophrenia.