摘要
过氧化物酶体增殖物活化受体γ协同刺激因子-1(PGC-1)与胰岛素抵抗(IR)形成密切相关。PGC-1可加速肝脏糖异生进程,诱发肝内IR,同时又可通过影响胰岛β细胞葡萄糖刺激的胰岛素分泌(GSIS)引起胰岛β细胞IR。另一方面,PGC-1表达增加可减少骨骼肌脂肪比重,增加有氧肌肉类型和胰岛素敏感性,从而减轻骨骼肌IR。PGC-1基因Gly482Ser多态性与IR显著相关,在2型糖尿病患者中,携带Ser/Ser基因型者较携带Gly/Gly基因型者具有更高的空腹胰岛素浓度和IR指数;携带Gly/Gly基因型的正常糖耐量者,较Ser/Ser基因型携带者表现为更低的胰岛素分泌。
Peroxisome proliferator-activated receptor gamma coaetivator-1（PGC-1） gene is associated with insulin resistance,PGC-1 gene accelerates gluconeogenesis process and induces insulin resistance in liver, mean- while causes insulin resistance in islet β cells by influencing glucose-stimulated insulin secretion （GSIS）. On the other hand, the increase of PGC-1 gene expression can decrease proportion of fat, increase aerobic muscle type and improve insulin sensitivity in skeletal muscle tissue. Gly482Ser variation of PGC-1 gene was confirmed to be related to insulin resistance. The concentration of fasting insulin and the index of insulin resistance were higher in Ser/Ser genotype than those in Gly/Gly genotype in type 2 diabetic patients. Otherwise, the secretion of insulin in Gly/Gly genotype was more lower than that in Ser/Ser genotype in people with normal glucose tolerance.
出处
《国际内分泌代谢杂志》
2006年第4期257-259,共3页
International Journal of Endocrinology and Metabolism
