脊髓P物质在大鼠佐剂型关节炎发病中的作用

The Effects of Substance P in Rat Spinal Cord on the Pathogenesis of AA

为探讨脊髓背角Ｐ物质（ＳＰ）在自身免疫性疾病发病中的作用，本实验以大鼠佐剂型关节炎（ＡＡ）为动物模型，观察免疫反应高峰期ＡＡ大鼠的病情、体内细胞免疫功能及中枢神经系统（ＣＮＳ）部分区域ＳＰ含量的变化。结果发现，脊髓蛛网膜下腔注射（ｉｔｈ）辣椒素（Ｃａｐ）耗竭脊髓背角ＳＰ后，ＡＡ病情ｂｕ重，免疫反应高峰期细胞免疫功能亢进，提示脊髓背角ＳＰ可能负向调节机体的免疫反应，从而具有一定的自身保护作用。

With a rat adjuvant arthritis(AA)model,the effects of substance P(SP)in spinal dorsal horn on the pathogenesis of autoimmune diseases were investigated. Capsaicin(Cap)was injected intra-thecally to exhaust SP in spinal dorsal horn. In Cap-pretreated AA group, the content of SP in spinal dor horn decreased with the exacerbated clinical severity and an in creased cellular responsibility in contrast to the control AA group. The results suggest that increased SP content in the spinal dorsal horn might suppress the immune response through an unknown negative feedback circuit to protect the body from excessive immune reaction in AA rat.