摘要
对制药公司来说，重组细胞药物靶点的表达和纯化是一项很有挑战性的任务。由于此药物涉及范围广及其高流通量，焦点通常集中在核心设备上。为了筛选靶点，需要大量的高纯度蛋白质，以便在药物发现期间，可进行功能分析或者利用结晶学进行结构研究。与生物制药学一样，蛋白质变得越来越重要，对其需求也越来越多。
The expression and purification of recombinant drug targets is a challenging task for pharmaceutical companies. Usually it is centralised in core facilities, because of the large scales involved and a demand for high throughput. Large numbers of proteins with good purity are required for screening targets and functional assays during drug discovery or for structural studies by crystallography, This demand has increased even more since proteins have grown in importance as biopharmaceuticals.
