摘要
对１１名单甲脒包装女工作为期４个月的健康效应的前瞻定群调研。下午班后双手单甲脒污染量为６．３８ｍｇ／ｃｍ２，尿中总浓度为０．４１４ｍｇ／Ｌ接触前为０．０８１ｍｇ／Ｌ；显著表现为头昏、嗜睡、乏力、皮疹、血压下降、心电图异常及尿中儿茶酚胺代谢产物ＶＭＡ减少。累计接触水平与症状体征积分、血压降幅及尿ＶＭＡ浓度间都存在接触－效应关系，提示脒类农药中毒的关键是心血管损害，系通过中枢儿茶酚胺α２受体的激动和对心肌直接损害所致。
A prospective cohort study on the cardiovascular effect of BTS 27271(halfmoiet of amitraz)among 11 women packers is reported.Exposure assessment was conducted with measurement of the hand contamination ,and biological monitoring the total urinary excretion of this chemical and metabolites.The main clinical manifestations were dizziness,somnolence,extreme fatigue,rashes,drop of blood pressure,abnormalities on EKG,and decrement of urinary VMA.Exposure effect relationship was demonstrated.The results suggested that the prominent mechanism of formamidines toxicity is agonizing the alpha 2 adrenal receptor and myocardium damage,which provide clue for improving diagnosis and treatment of intoxication with such chemicals.
基金
国家教委博士点基金
