慢性阻塞性肺病患者血浆内皮素水平与肺血流动力学的关系

RELATIONSHIP BETWEEN PLASMA ENDOTHELIN LEVELS AND PULMONARY HEMODYNAMICS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

本文报告采用放射免疫方法测定慢性阻塞性肺病24例(COPD)患者体静脉、肺动脉、体动脉血的血浆ET-1水平,并与16例正常对照组作了比较。COPD患者尚进行了肺动脉压力直接测定。结果表明,COPD患者ET-1水平显著高于正常组(p〈0.001);肺动脉高压(PAH)组ET-1水平显著高于非PAH组(p〈0.05),本文还分析了ET参与COPD患者血浆ET-1水平的升高在PAH形成中可能是参与发病的因素之一。血浆ET水平的测定可能为了解COPD患者的病理生理变化和临床病程提供一项有意义的参考指标。

Plasma Endothelin-1 (ET-1) levels were measured with radioimmunoassay method in 24 patients with chronic obstructine pulmonary disease (COPD) and 16 controls. Gatheterization were undertaken in COPD patients to measure pulmonary artery pressure. The results showed that ET-1 levels in COPD patients were significantly higher than those in the controls (p<0.01).Meanwhile, the patients with pulmonary artery hypeartension (PAH) had higher ET-1 levels than those without PAH (p<0.05). It is suggested that ET-1 may play a role in the pathogenesis of PAH in COPD patients. Mesurement of plasma ET levels may be helpful in understanding the phathophysiology and clinical course in COPD patients.