实验性白色念珠菌感染对小鼠脾细胞NK活性的抑制作用

SUPPRESSION OF NATURAL KILLER CELL ACTIVITY DURING THE COURSE OF CANDIDA ALBICANS INFECTION IN MICE

以脾细胞为效应细胞、ＹＡＣ—１细胞为靶细胞，用ＬＤＨ释放法观察了白色念珠菌腹腔感染小鼠ＮＫ细胞活性的变化。结果表明，白色念珠菌严重感染可抑制ＫＮ细胞活性，以感染后４～８天抑制最明显，１６天左右恢复至正常。免疫功能低下小鼠更易受到白念菌的侵袭。

This study observed the change of natural killer cells against YAC-1cell activity with LDH release method in mice which,were infected by candida albicans.The results showed that the actlvity of natural killer cytotoxicity was suppressed whenthe mice were seriously infected with Candida albicans,which was lowest in 4 8 daysafter the intection and was restored to normal about at the 16th day.The mice whoseimmune function was suppressed were easily invaded by candida albicans.