氨基磺酸催化合成异丁醛1,2-丙二醇缩醛

Synthesis of Isobutyraldehyde 1,2-propanediol Acetal with Aminosulfonic Acid as Catalyst

以氨基磺酸为催化剂,对以异丁醛和1,2-丙二醇为原料合成异丁醛1,2-丙二醇缩醛进行了研究。较系统地研究了醛醇摩尔比,催化剂用量,反应时间,带水剂诸因素对收率的影响,结果表明:氨基磺酸是合成异丁醛1,2-丙二醇缩醛的良好催化剂,最佳反应条件为:异丁醛为0.2 mol,n(异丁醛)∶n(1,2-丙二醇)=1∶1.5,催化剂用量为反应物总质量的6.8%,带水剂环己烷15 ml,反应时间60 min。上述条件下,异丁醛1,2-丙二醇缩醛的收率可达71.15%。

Isobutyraldehyde 1,2 - propanediol acetal （ Ⅰ ）was synthesized from isobutyraldehyde （ Ⅱ） and 1,2 - propanediol（ Ⅲ） in the presence of aminosulfonic acid （ Ⅳ ） as catalyst. The effects of molar ratio of aldehyde to alcohol, amount of catalyst, reaction time and water carrying agent on product yield were studied. The result showed that（ Ⅳ ）was an excellent catalyst. The optimum reaction conditions were as follow： isdmtyraldehyde was 0.2mol, the molar ratio of n （Ⅱ ） ： n （ Ⅲ） = 1 ： 1.5, the amount of catalyst was as 6.8% as the reactants, the water carrying agent was 15ml, and the reaction time was 60 mins. Under these conditions,the yield of（I）could reach 71.15%.