摘要
本文介绍了RGS蛋白对阿片受体-腺苷酸环化酶活性的调节;阿片受体长期激活对细胞内钙离子、细胞浆酸碱度以及线粒体膜电势的影响;以及阿片受体不通过G蛋白对细胞膜外向整流钾通道的调节机理。
The modulation of RGS protein on opioid receptor and adenyl cyclase; the influence on inner cell calcium, the acidity in cell plasma and the mitochondrial membrane potential after long term activation of opioid receptor; the possible mechanism about the modulatory effect of opioid receptor on outwardly rectifying potassium channel which were independent of G protein were talked about in this article.
出处
《中国药物依赖性杂志》
CAS
CSCD
2006年第3期173-176,共4页
Chinese Journal of Drug Dependence
基金
国家重点基础研究发展计划(973计划)"精神活性物质依赖的生物学基础及防治"(2003CB515400)资助项目
关键词
RGS蛋白
阿片受体
线粒体膜电势
外向整流钾通道
RGS protein
opioid receptor
mitochondrial membrane potential
outwardly rectifying potassium channel
