细胞间黏附分子-1和P-选择素的表达与非小细胞肺癌关系的研究

A Study of the expression of ICAM-1 and P-selectin in human non-small cell lung cancer

目的探讨细胞间黏附分子-1(ICAM-1)和P-选择素在肺癌转移机制中的作用。方法采用免疫组化SP法对52例原发性肺癌组织的ICAM-1及P-选择素的表达进行检测。结果(1)肺癌的ICAM-1和P-选择素阳性表达明显高于癌旁组织;(2)ICAM-1及P-选择素在腺癌组织中的阳性表达率显著高于鳞癌,两者在Ⅲ+Ⅳ期患者的阳性表达明显高于Ⅰ+Ⅱ期;(3)肺癌中有淋巴结转移的ICAM-1的阳性表达率显著高于无淋巴结转移,而P-选择素的表达与淋巴结转移无明显相关性。结论ICAM-1和P-选择素可能与肺癌的浸润转移有关。

Objective To investigate the role of ICAM-1 and P-selectin in human non-small cell lung cancer. Methods Immunohistochemieal staining method （SP） was used to detect the expression of ICAM-1 and P-selectin in non-small cell lung cancer. Results （ 1 ） The positive rate of ICAM-1 and P-seleefin expression in lung cancer was significantly higher than those of normal tissue;（ 2 ）The expression of ICAM-1 and P-selectin in adenocareinoma was higher than that of the squamous cell carcinoma,the expression of both in stage Ⅲ ＋ Ⅳ was higher than that of stage Ⅰ ＋ Ⅱ; （3） The positive expression of ICAM-1 in patients with lymph node metastasis was higher than no lymph node metastasis, but P-selectin is not. Conclusions ICAM-1 and P-seleetin might be associated with metastasis in lung cancer.