糖尿病并发冠心病血浆内皮素及心钠肽含量变化及其临床价值

Plasma Endothelin and Atrial Natriuretic Peptide contents and their clinical significance in Diabetic Patients with Coronary Heart Disease

目的测定2型糖尿病(T2DM)并发冠心病(CHD)病人血浆血管内皮素(ET)、心钠素(ANP)含量,探讨其在本病发生与发展中的作用和对临床诊断的价值。方法选择64例糖尿病(DM)病人,其中并发CHD组32例,未并发CHD组32例,以放射免疫分析(RIA)法检测血浆ET、ANP水平,进行分析,并与30名健康体检者作比较。结果DM并发CHD组血浆ET、ANP含量显著高于未并发CHD的DM组及正常健康人组(P<0.01);DM无并发CHD组血浆ET、ANP含量显著高于正常对照组(P<0.05)。影响因素除与本身有无并发CHD外,尚与病程、年龄有关。结论DM并发CHD病人血浆ET、ANP变化可能参与了本病的发病过程,可作为判断病情程度及疗效评价的指标。

Objective To measure the content of plasma endothelin （ET） and atrial natriuretic peptide ET in diabetic patients （pts） with coronary heart disease （CHD） to investigate the roles of ET and ET in the occurrence and development of the disease and their value for clinical diagnosis. Methods 64 Sixty - four pts （32 pts with CHD and 32 pts without CHD） were selected to measure their plasma ET and ANP levels by radioimmunoassay（RIA）. The plasma ET and ANP levels in pts were compared with that in 30 healthy controls. Results The plasma ET and ANP levels in diabetic patients with CHD were markedly higher than that in diabetic patients without CHD and healthy people （P 〈 0.01 ）, The plasma ET and ANP levels in diabetic patients without CHD were markedly higher than that in healthy controls （P 〈 0.05）. Conclusion The plasma ET and ANP levels in diabetic patients with CHD could be involved in the pathogenesis of the disease, they might be used as an indicator for severity of disease and efficacy assessment.