子痫前期患者血清中IL-6、TNF-α的表达

Expression of Interleukin-6 and Tumor Necrosis Factor Alpha in Pre-eclampsia

目的探讨血清中IL-6、TNF-α的表达在子痫前期发病中的作用。方法应用放射免疫法分别对33例重度子痫前期患者、35例轻度子痫前期患者及36例正常妊娠妇女进行血清中IL-6、TNF-α的含量测定。结果①子痫前期组患者血清中IL-6(237.24±32.13)pg/m l、TNF-α(1.82±0.28)ng/m l的表达显著高于正常妊娠组IL-6(118.79±15.71)pg/m l、TNF-α(1.18±0.14)ng/m l(P<0.05)。②重度子痫前期组患者血清中IL-6(239.72±21.19)pg/m l、TNF-α(1.93±0.15)ng/m l的表达显著高于轻度子痫前期组IL-6(197.79±19.9)pg/m l、TNF-α(1.59±0.13)ng/m l(P<0.05);③轻度子痫前期组患者血清中IL-6、TNF-α的表达显著高于正常妊娠组(P<0.05)。结论血清中IL-6、TNF-α的高度表达与子痫前期的发病密切相关,两者在子痫前期的发生、发展中起到重要作用。

Objective To study the role of the expression of interleukin -6 （IL -6） and tumor necrosis factor alpha（ TNF -α） in pre - eclampsia. Methods IL - 6 and TNF -α leveld in serum were measured by radioimmunoassay in 33 severe pre -eclampsia patients ,35 mild pre -eclampsia patients and 36 normal pregnant women. Results ①The expression of 1L - 6 and TNF -α were （237.24 ± 32. 13 ）pg/ml and（ 1.82 ±0. 28 ）ng/ml in group of pre -eclampsia compared to（ 118. 79 ± 15.71 ） pg/ml and（ 1.18 ±0. 14）ng/ml in group of normal pregnant, the differences were significant （ P 〈0.05）. ②The expression of IL -6 and TNF -α were （239.72 ± 21.19）pg/ml and （1.93 ± 0. 15 ）ng/ml in group of sever pre -eclampsia compared to（ 197.79 ± 19.9）pg/ml and（ 1.59 ± 0. 13 ） ng/ml in group of mild pre - eclampsia, the differences were significant, too （ P 〈 0. 05 ）. ③The expression of IL-6 and TNF-α in group of mild pre -eclampsia was significantly higher than that in the gruop of normal pregnant （ P 〈 0.05）. Conclusion The high expressions of IL - 6 and TNF -α have a positive relationship with the degree of hypertensive disorder complicating pregnancy and play an important role in the pathogenesis and development of this disease.