临床分离病原菌谱及药物敏感性变化

Variation of Clinical Bacterial Isolates and Drug Sensitivity

目的 了解临床分离病原菌种类分布及对抗菌药物敏感性的变化。方法 回顾性分析2002～2005年，从临床标本分离到的1524株病原菌及药敏情况。结果 革兰氏阴性菌的比例为72．1％-57．5％，呈下降趋势；阳性菌为19．8％，29．2％，呈上升趋势；白色念珠菌为8．1％～13．3％，呈上升趋势。葡萄球菌对抗菌药物耐药性严重，仅对万古霉素敏感率〉90％；主要G^-1杆菌对多粘菌素B、泰能的药物敏感率为73．3％-100．0％。结论 病原菌的构成及药敏性不断变化，与抗菌药物使用不当有关，实验室应加强对细菌的检测，指导临床合理用药。

Objective To change in drug sensitivity. Methods investigate the distribution of clinical bacterial isolates and the A total of 1524 stains from clinical samples and their antibiotic drug sensitivity during 2002 to 2005 were studied retrospectively. Results The amount of Gram - negtive bacteria went down（72. 1% - 57.5% ）;Gram- positive bacteria and Candida albicans went up （19.8% - 29.2% ）. Drug Sensitivity rates of Staphylococcus went down seriously, to vancomycin were more than 90% ;Drug Sensitivity rates of Gram -negative bacteria to sefotaxime B and imipenem were between 73.3% - 100. 0%. Conclusion The variation of drug sensitivity and distribution of clinical bacterial isolates are related to the improper use of antibiotics. The strengthened supervision and reasonable advice for medicine should be given in the laboratory.