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非索非那定的微生物转化制备 被引量：1

Preparation of Fexofenadine by Microbial Transformation
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摘要 研究了以普拉特链霉菌SIPI-76微生物转化特非那定为非索非那定的条件。考察碳源、氮源等培养基成分,底物的加入浓度、时间,生长细胞培养时的pH、温度、溶氧等参数对转化的影响。表明在优化条件下转化率达到90%。 The microbial transformation conditions for preparation of fexofenadine from terfenadine by S. platensis SIPI-76 were studied. The factors affecting on the transformation were investigated, such as carbon and nitrogen source of medium, addition time and concentration of the substrate, pH, temperature, dissolved oxygen during cell growth. Under the optimal conditions, the transformation efficiency of terfenadine to fexofenadine was 90%.
作者 刘雪峰 冯军 程晴华 赵文杰
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第7期449-451,共3页 Chinese Journal of Pharmaceuticals
关键词 非索非那定 特非那定 微生物转化 fexofenadine terfenadine microbial transformation
分类号 TQ464.9 [化学工程—制药化工]
  • 相关文献

参考文献9

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二级参考文献8

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共引文献5

同被引文献9

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  • 9吕彬华,杨雪艳,吴范宏.抗组胺药非索非那定盐酸盐的合成[J].中国药物化学杂志,2004,14(2):96-98. 被引量：6

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中国医药工业杂志
2006年 第7期

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