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解偶联蛋白2基因多态性与糖尿病合并冠心病的关系 被引量：1

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摘要 目的:探讨解偶联蛋白2基因(UCP-2)8号外显子3'-末端(3'-UTR)45bp插入/缺失多态与糖尿病合并冠心病的关系。方法:201例糖尿病患者(其中45例伴有冠心病,156例不伴冠心病),检测所有患者的基因组DNA,用聚合酶链反应PCR方法对UCP-2基因进行扩增,记录各组UCP-2等位基因及基因型频率并进行比较。结果:UCP-2基因8号外显子3'-末端(3'-UTR)45bp插入/缺失多态在伴有冠心病组和不伴冠心病组中基因型分布差异无显著性,两组的等位基因频率差异亦无显著性(χ2=0.08,P>0.05)。结论:UCP-2基因8号外显子3'-末端(3'-UTR)45bp插入/缺失多态与中国人糖尿病并发冠心病无相关性。
作者 孙艳荪 苏本利 李昌臣
机构地区 北京大学深圳医院特诊区 大连医科大学附属第二医院内分泌科 大连医科大学附属第一医院内分泌科
出处 《实用医学杂志》 CAS 2006年第13期1517-1518,共2页 The Journal of Practical Medicine
关键词 糖尿病 冠心病 解偶联蛋白-2 基因 多态性
分类号 R587.1 [医药卫生—内分泌] R541.4 [医药卫生—心血管疾病]
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参考文献9

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共引文献10

同被引文献23

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实用医学杂志
2006年 第13期

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