N,N′-二苄基乙二胺类番荔枝内酯简化类似物的合成

Synthesis of Simplified Analogue of Acetogenin Bearing N,N′-dibenzyl Ethylenediamine Moiety

运用生物电子等排原理及简化策略,设计含乙二胺结构片段的番荔枝内酯简化类似物。通过N,N′-二苄基乙二胺与两个手性环氧片段依次拼接,合成了手性简化类似物。其结构经1H NMR,13C NMR和MS表征。

A simplified analogue of acetogenin was designed and synthesized through N,N′-dibenzyl ethylenediamine treating with two chrial epoxide segments successively. The structure was confirmed by 1^H NMR, 13^C NMR and MS.